Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage
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چکیده
منابع مشابه
The emerging role of FTY720 (Fingolimod) in cancer treatment
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-phosphate 1 receptor. FTY720 also demonstrates a proven efficacy in multiple in vitro and in vivo cancer models, suggesting a potential therapeutic role in cancer patients. A potential anticancer mechanism of FTY720 is...
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پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...
15 صفحه اولComplications of Subarachnoid Hemorrhage in Patients Admitted to Imam Khomeini Hospital in Urumia
Background and Aim: Secondary complications management of Subarachnoid Hemorrhage (SAH) is one of the therapeutic challenging issues during ICU[A1] admission. The complications of patients with SAH admitted to the ICU of Imam Khomeini Hospital of Urumia were investigated in this study. Methods and Materials/Patients: In this descriptive study, the clinical complications of the patients with ...
متن کاملExperimental Subarachnoid Hemorrhage in Spontaneously Hypertensive Rats
The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assessed quantitatively by spectrophotometric determination of Evans blue extravasati...
متن کاملSubarachnoid hemorrhage-induced hydrocephalus in rats.
BACKGROUND AND PURPOSE Hydrocephalus is an important complication of subarachnoid hemorrhage (SAH). We investigated the occurrence of acute hydrocephalus in a rat SAH model. METHODS SAH was induced by endovascular perforation in adult male Sprague-Dawley rats (n=36). Sham rats (n=8) underwent the same procedure without perforation. MRI was performed 24 hours after SAH and the volume of the ve...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2015
ISSN: 1742-2094
DOI: 10.1186/s12974-015-0234-7